A drawing of a brain with "Parkinson's disease" written on the inside

3 Ways to Slow the Progression of Parkinson’s Disease

How to Prevent Parkinson's Disease

Aging is the biggest risk factor for Parkinson’s disease, but there are ways to help reduce its progression. Parkinson's disease is the second most common disorder as a result of degeneration of brain cells. The condition affects around 1 million Americans and worldwide about 1 in 600 people over the age of 65 suffer from Parkinson’s. In this article we look at how to prevent Parkinson’s disease. We also look at the disease progression and its risk factors.

The condition was initially described around two centuries ago, but researchers are still trying to unravel exactly what causes the changes in the brain. There is still no treatment to cure or stop the progression of the disease. However, as for other chronic conditions associated with aging, it is becoming clear that healthy habits slow down the aging process and prevent or delay the onset of Parkinson’s disease.

What is Parkinson’s Disease?

Dopamine is an important brain chemical that is responsible for transmitting signals between nerve cells, both in the brain and in the rest of the body. In Parkinson’s disease, the brain cells that produce dopamine gradually die and the symptoms become progressively worse as dopamine levels decrease.

Dopamine is involved in controlling conscious body movement, mood, memory, and thinking. Changes in movement are the most obvious symptoms of Parkinson’s and include:

  • Tremors, first in the fingers or thumbs and then later the hands.
  • Slower movement.
  • Stiffness in the body that does not improve as the person moves around.
  • Stooping or slouching posture.
  • Increase in sudden movements while asleep.
  • A mask-like, emotionless, facial expression.
  • Arms that do not swing normally when walking.
  • Softer, possibly hoarse, speech.
  • Changes in handwriting (typically it becomes smaller and less clear).

Symptoms of Parkinson’s that are not related to movement include changes in thinking, including a shorter attention span, memory loss, and unclear speech. Those affected might also experience mood and sleep disorders. Other physical symptoms include constipation, fatigue, dizziness, and loss of taste or smell.

The actual symptoms, and the how rapidly they become worse, vary between those with Parkinson’s. The first three symptoms listed above are the most typical of the condition and doctors look out for at least two of them before confirming a diagnosis of Parkinson’s.

Initially, however, symptoms of the disorder may be hardly noticeable and the non-movement symptoms usually set in before the changes in movement become evident. This means the brain changes are fairly advanced by the time Parkinson’s is diagnosed.

What Causes Parkinson’s Disease?

There is as yet no treatment to prevent or halt the gradual dying off of the brain cells that produce dopamine. The main reason is that, despite decades of research, it is still unclear exactly why and how this happens.

Abnormal Biochemical Process

It now appears probable the damage to brain cells is the result of faulty biochemical processes. For example, many studies are now focus on alpha-synuclein, a protein involved in regulating the flow of dopamine. In people with Parkinson’s there is an overproduction of this protein, some of it in a mutated form, and scientists believe that this might be toxic to brain cells.

Genetic and Environmental Factors

In the meantime, experts do know that a combination of genetic, environmental, and lifestyle factors contribute to the risk of developing Parkinson’s disease.

About 10% to 15% of cases can be linked directly to hereditary factors. Furthermore, research has shown that small variations in one or more of about 20 genes might increase the risk of Parkinson’s. But not all people who have these gene variations develop the disease and that is where environmental and lifestyle factors come in.

Exposure to certain pesticides and herbicides is one such risk factor. These chemicals have been found in the brains some Parkinson’s sufferers and the incidence of the condition is higher in agricultural workers than among the general population. Previous brain trauma is another risk factor.


Aging, with the known deterioration in normal cellular function throughout the body, is the most significant risk factor for developing Parkinson’s. As with most other chronic conditions, healthy lifestyle choices appear to also have a protective role in Parkinson’s disease. Healthy habits reduce the inflammation that contributes to cell damage and also helps to maintain optimal functioning of the whole body.

Parkinson's Progression

The progression of Parkinson's disease varies from person to person, but it typically follows a pattern of gradual worsening of symptoms over time. In the early stages, symptoms may be mild and may only affect one side of the body. As the disease progresses, symptoms become more severe and may begin to affect both sides of the body. People with Parkinson's disease may also experience non-motor symptoms such as depression, anxiety and sleep disturbances, which can also worsen over time.

Preventing or Slowing Parkinson’s Progression


Thus far, physical activity throughout life is the one lifestyle factor with the strongest research support for reducing the risk of Parkinson’s disease.

Aerobic exercise benefits brain health at a cellular level. It gets the heart beating faster, so that more oxygen is supplied to the brain – this reduces inflammation and also improves cognitive function.

Studies which follow large groups of people over many years have found that there is a lower incidence of Parkinson’s in those who reported moderate to high levels of physical activity in midlife. Persons who exercised regularly and did develop the condition experienced slower progression of symptoms.

Furthermore, studies of people with Parkinson’s disease have shown that regular exercise could slow down progression and improve quality of life. It is self-evident that building up endurance, muscle strength, and balance in the early stages of Parkinson’s will provide a reserve of physical function as the disease progresses.


The following are dietary guidelines, backed by some research, which may help to prevent Parkinson’s or slow down disease progression:

  • Eat organically grown foods. Not only are they more nutritious but there is also reduced exposure to pesticides.
  • Eat more vegetables. It appears that a higher intake of folic acid, one of the B-vitamins, may reduce the risk of Parkinson’s. This vitamin is found mainly in vegetables, especially green leafy vegetables.
  • Make sure that you maintain adequate levels of vitamin D. Researchers found that about 70% of persons with early-stage Parkinson’s have low levels of this vitamin. Certain foods, especially oily fish, contain vitamin D but usually not enough. So be sure to expose your skin to sunlight for about 20 minutes a day.
  • Omega-3 fatty acids also appear to have a protective effect against Parkinson’s. The anti-inflammatory effect of omega-3 helps to prevent cell degeneration and death.
  • Many persons diagnosed with Parkinson’s were also found to have a deficiency of the enzyme CoQ10. This enzyme has been shown to prevent dopamine loss and slow progression of the disease. You can either take CoQ10 supplements or eat more organ meats and wild-caught fish.

Stress Reduction

Experts are currently theorizing that prolonged emotional stress might trigger Parkinson’s disease. It is known that continuous high levels of adrenalin and cortisol, and the inflammation it causes, damages brain cells.

More than a 100 years ago, a doctor observed that prolonged anxiety and emotional shock often preceded the onset of Parkinson’s. Furthermore, studies have found that there is a higher incidence of the condition in people who suffered extreme psychological stress, for example, victims of the holocaust and ex-prisoners of war.

So, exercise, mindfulness, meditation, and other activities that relieve stress can also prevent or delay the onset of Parkinson’s disease in susceptible individuals.

Take Control of Your Health

As more people live longer, the incidence of chronic conditions is increasing, including Parkinson’s disease.

However, as in the case of other chronic conditions, evidence is building that keeping your body and mind healthy might prevent or slow down the progression of Parkinson’s.

Exercise regularly, eat a healthy diet and manage your stress to maintain the best possible quality of life.